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KMID : 0350519950480010197
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.197 ~ p.206
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Total Cholesterol Levels and Its Relationships to Lipoprotein Cholesterol, Blood Pressure and Body Mass Index in Primary School Chidren
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Abstract
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Serum lipid and lipoprotein cholesterol levels are predictive of atherosclerotic lesions and cardiovascular disease in adults. However, the early stages of atherosclerosis begin in childhood, and these early atherosclerotic lesions are associated
with
levels of serum lipids and lipoprotein cholesterol fractions in chidren and adolescents.
A total of 1,115(591 males and 524 females) primary school children aged 6 to 12 participated in our cross sectional study of lipid analyses. After an overnight fasting, venipunctures were performed to measure serum total cholesterol Heights,
weights
and blood pressures were checked using conventional methods. Children with hypercholesterolemia(total cholesterol >175 mg/100 ml) who are considered to be a risk group of premature atherosclerosis, were selected and divided into two groups as
moderate
risk group(total cholesterol 175 ~ 199 mg/100 ml) and high risk group(total cholesterol >200 mg/100 ml). High-density lipoprotein-cholesterol(HDL-C) and triglyceride levels were measured in hypercholesterolemic children.
@ES Thfe results were as follows :
@EN 1. The mean total cholesterol level of the subjects was 162.77±23.16 mg/100 ml and was significantly lower in 6-year-old group than in other age groups. There was no significant difference in mean level between male and female.
2. The frequencies of the subjects with hypercholesterolemia in moderate and high risk group were 20.0%, 6.6% in male, and 23.5%, 4.6% in female, respectively. No significant differences in frequencies were observed between male and female.
3. The total cholesterol levels of 5th, 25th, 50th, 75th and 95th percentile for subjects were 128, 148, 162, 177 and 202 mg/100 ml, respectively.
4. In group with hypercholesterolemia, total cholesterol level was significantly correlated with LDL-C(r=0.7677) and HDL-C(r=0.1470), but was not significantly correlated with triglycerides, blood pressures and Quetelet's indices.
5. The correlation coefficient between total cholesterol and LDL-C was significantly higher in high risk group(r=0.8054) than in moderate risk group(r=0.4253).
These results can be used as references for the mean and percentile values of total cholesterol, and for the frequency of hypercholesterolemia in children aged 6 to 12.
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